8 However, majority of patients need pharmacotherapy to control their body weight effectively. Life style modification including healthy meal plan, increase of physical activity, and behavior intervention is an essential part of obesity management. 6, 7 Moreover, obesity management is important not only for the prevention of diabetes but also for the delay of diabetes related complications. 5 Reducing hyperglycemia is one of the most important prevention strategies for diabetes complications. 2, 3 Furthermore, for the individuals who already suffer from diabetes, a larger body weight reduction brought a better glucose control and health benefit on one year 4 and even longer term. Diabetes is the most hazardous obesity related comorbidity and it can be prevented by reducing body weight. 1 This is a serious global health problem and we need appropriate prevention strategies for obesity itself and obesity related comorbidities. The prevalence of obesity has doubled since 1980 and this trend has continued over time. Keywords: Obesity, Diabetes mellitus, Drug therapy, Cardiovascular disease, Diabetes complications This review focused on current evidences of anti-obesity medications related with diabetes, which is a major complication of obesity. In addition, there are many indirect evidences of the role of anti-obesity medications on diabetes prevention and its microvascular and macrovascular complications. Cardiovascular safety studies were conducted for lorcaserin and liraglutide (as an anti-diabetic medication). Orlistat and liraglutide have been tested for their effect on diabetes prevention as a primary outcome. As the goal of obesity management is to prevent obesity-related comorbidities, clinical trials were conducted to evaluate the effect of anti-obesity medications on cardiovascular risk factors including hyperglycemia. Food and Drug Administration for chronic treatment used in obesity management. There are five classes of anti-obesity medications approved by the U.S. However, pharmacotherapy is frequently required in addition to the lifestyle modification for effective reduction of body weight. Traditionally, lifestyle modification including reduced-calorie diet, physical activity, and behavior intervention is the core of obesity management. Diabetes is prevalent in obese population, and obesity management is the first step in preventing diabetes.
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